Table 2.

Stratification of Simulated Data

Cohort Name	Inclusion Criteria	Anticipation	p
Child early birth year	Child born < 1939	16 years	0.009
Child late birth year	Child born ≥ 1939	18 years	<0.0001
Child early death year	Child year of onset < 2000	26 years	0.0004
Child late death year	Child year of onset ≥ 2000	15 years	<0.0001
Child early death age	Child age onset < 61	21 years	<0.0001
Child late death age	Child age onset ≥ 61	11 years	0.003
Parent early death age	Parent age onset < 70	12 years	0.01
Parent late death age	Parent age onset ≥ 70	20 years	<0.0001

In n = 26 simulated parent-child pairs with independent and identically distributed ages of onset but ascertaining only those pairs whose onsets both fall within 1989–2013, all subsets of data stratified according to the variables defined in Table 3 of Pocchiari et al.¹³ still show significant anticipation.