Table 3.
Characteristics of Glu200Lys Data Sets
| Study Center | In Operation Since | n c.598G>A Individuals | n c.598G>A Parent-Child Pairs | Proportion of c.598G>A Individuals Ascertained Indirectly | Proportion of c.598G>A Individuals Who Are Asymptomatic |
|---|---|---|---|---|---|
| ANCJDR | 1993 | 24 | 7 | 42% | 8% |
| German CJD Surveillance | 1993 | 32 | 3 | 38% | 3% |
| MRC Prion Unit | 1991 | 57 | 29 | 25% | 23% |
| UCSF | 2001 | 104 | 58 | 73% | 37% |
| All | 217 | 97 | 52% | 25% |
Data from the four study centers varied in terms of the length of time for which data had been collected, the degree of indirect ascertainment, and the ascertainment of asymptomatic individuals with the mutation. See Material and Methods for details.