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. 2014 Oct 2;95(4):437–444. doi: 10.1016/j.ajhg.2014.08.011

Table 2.

Comparison of Signals of Population Differentiation

SNP ID Region Gene Jin et al.9data
Bhatia et al.23Data
WC FST Hudson FST Model-Based p Value Model-Based p Value
rs1541044 chr1: 100,125,058–100,183,875 0.0562 0.0439a 4.7 × 10−5 0.04
rs4460629 chr1: 153,401,959–153,464,086 0.0692 0.0650 6.8 × 10−7 2.1 × 10−4
rs12094201 chr1: 236,509,336 0.0561 0.0489 1.7 × 10−5 0.86
rs7642575 chr3: 31,400,165 0.0453 0.0393a 1.1 × 10−4 0.41
rs652888 chr6: 26,554,684–33,961,049 HLA 0.0711 0.0627 1.1 × 10−6 1.8 × 10−11
rs9478984 chr6: 151,555,551–151,569,258 0.0545 0.0596 2.1 × 10−6 0.02
rs10499542 chr7: 22,235,870 0.0461 0.0453 3.6 × 10−5 0.35
rs304735 chr7: 79,768,487–80,482,597 CD36 0.0946 0.0690 3.0 × 10−7 3.7 × 10−13
rs2920283 chr8: 143,754,039–143,758,933 PSCA 0.0468 0.0532 7.6 × 10−6 6.4 × 10−7
rs1498487 chr11: 5,034,229–5,421,456 HBB 0.0617 0.0464 2.4 × 10−5 1.7 × 10−7
rs4883422 chr12: 7,189,594 0.0472 0.0461 3.0 × 10−5 1.3 × 10−3
rs6491096 chr13: 25,488,362 0.0472 0.0373a 1.5 × 10−4 0.4
rs1075875 chr16: 47,595,721 0.0766 0.0608 1.3 × 10−6 NAb
rs6015945 chr20: 59,319,574 0.0627 0.0550 4.3 × 10−6 0.5

We recreated Table 2 from Jin et al.9 by analyzing the same data with the Hudson instead of the WC estimator. We also estimated the p value at each SNP by using the reported FST = 0.0007 of Jin et al.9 and a model-based approach.24 Finally, we report the model-based p value of the most significant SNP in the region from the parallel study by Bhatia et al.23 We note that results reported in that paper were more significant than those reported here because Bhatia et al. analyzed additional populations. All positions are from UCSC Genome Browser build hg18.

a

These loci fell below the threshold for the 99.99th percentile (0.0452) when the Hudson estimator was used.

b

This locus was not available (NA) because it lacked data in the Bhatia et al.23 study.