Table 2.
Comparison of Signals of Population Differentiation
SNP ID | Region | Gene |
Jin et al.9data |
Bhatia et al.23Data |
||
---|---|---|---|---|---|---|
WC FST | Hudson FST | Model-Based p Value | Model-Based p Value | |||
rs1541044 | chr1: 100,125,058–100,183,875 | – | 0.0562 | 0.0439a | 4.7 × 10−5 | 0.04 |
rs4460629 | chr1: 153,401,959–153,464,086 | – | 0.0692 | 0.0650 | 6.8 × 10−7 | 2.1 × 10−4 |
rs12094201 | chr1: 236,509,336 | – | 0.0561 | 0.0489 | 1.7 × 10−5 | 0.86 |
rs7642575 | chr3: 31,400,165 | – | 0.0453 | 0.0393a | 1.1 × 10−4 | 0.41 |
rs652888 | chr6: 26,554,684–33,961,049 | HLA | 0.0711 | 0.0627 | 1.1 × 10−6 | 1.8 × 10−11 |
rs9478984 | chr6: 151,555,551–151,569,258 | – | 0.0545 | 0.0596 | 2.1 × 10−6 | 0.02 |
rs10499542 | chr7: 22,235,870 | – | 0.0461 | 0.0453 | 3.6 × 10−5 | 0.35 |
rs304735 | chr7: 79,768,487–80,482,597 | CD36 | 0.0946 | 0.0690 | 3.0 × 10−7 | 3.7 × 10−13 |
rs2920283 | chr8: 143,754,039–143,758,933 | PSCA | 0.0468 | 0.0532 | 7.6 × 10−6 | 6.4 × 10−7 |
rs1498487 | chr11: 5,034,229–5,421,456 | HBB | 0.0617 | 0.0464 | 2.4 × 10−5 | 1.7 × 10−7 |
rs4883422 | chr12: 7,189,594 | – | 0.0472 | 0.0461 | 3.0 × 10−5 | 1.3 × 10−3 |
rs6491096 | chr13: 25,488,362 | – | 0.0472 | 0.0373a | 1.5 × 10−4 | 0.4 |
rs1075875 | chr16: 47,595,721 | – | 0.0766 | 0.0608 | 1.3 × 10−6 | NAb |
rs6015945 | chr20: 59,319,574 | – | 0.0627 | 0.0550 | 4.3 × 10−6 | 0.5 |
We recreated Table 2 from Jin et al.9 by analyzing the same data with the Hudson instead of the WC estimator. We also estimated the p value at each SNP by using the reported FST = 0.0007 of Jin et al.9 and a model-based approach.24 Finally, we report the model-based p value of the most significant SNP in the region from the parallel study by Bhatia et al.23 We note that results reported in that paper were more significant than those reported here because Bhatia et al. analyzed additional populations. All positions are from UCSC Genome Browser build hg18.
These loci fell below the threshold for the 99.99th percentile (0.0452) when the Hudson estimator was used.
This locus was not available (NA) because it lacked data in the Bhatia et al.23 study.