Table 1.
Biased Gene Conversion Modifies Summary Statistics of the Site Frequency Spectrum
| Population | Type of SNP | Tajima’s D (95% CI) | Fay and Wu’s H (95% CI) | Mean DAF (95% CI) |
|---|---|---|---|---|
| Pygmy | WW or SS | −0.430 (−0.479 to −0.383) | 0.264 (0.192 to 0.332) | 0.271 (0.265 to 0.277) |
| SW | −0.465 (−0.515 to −0.415) | 0.248 (0.186 to 0.317) | 0.270 (0.264 to 0.276) | |
| WS | −0.385 (−0.438 to −0.334) | −0.048 (−0.125 to −0.031) | 0.297 (0.291 to 0.304) | |
| YRI | WW or SS | −0.357 (−0.411 to −0.300) | 0.182 (0.106 to 0.255) | 0.282 (0.275 to 0.288) |
| SW | −0.389 (−0.444 to −0.333) | 0.172 (0.099 to 0.243) | 0.281 (0.274 to 0.287) | |
| WS | −0.319 (−0.374 to −0.268) | −0.123 (−0.206 to −0.041) | 0.307 (0.300 to 0.315) | |
| Sandawe | WW or SS | −0.349 (−0.401 to −0.294) | 0.159 (0.080 to 0.231) | 0.284 (0.278 to 0.291) |
| SW | −0.386 (−0.441 to −0.333) | 0.152 (0.075 to 0.225) | 0.282 (0.276 to 0.289) | |
| WS | −0.311 (−0.365 to −0.257) | −0.139 (−0.227 to −0.050) | 0.309 (0.302 to 0.316) | |
| Hadza | WW or SS | −0.011 (−0.072 to 0.046) | −0.013 (−0.109 to 0.075) | 0.319 (0.311 to 0.326) |
| SW | −0.036 (−0.094 to 0.022) | −0.003 (−0.087 to 0.081) | 0.316 (0.309 to 0.323) | |
| WS | 0.015 (−0.050 to 0.073) | −0.280 (−0.378 to −0.188) | 0.340 (0.332 to 0.348) | |
| CEU | WW or SS | 0.102 (0.038 to 0.168) | −0.310 (−0.415 to −0.208) | 0.348 (0.340 to 0.357) |
| SW | 0.057 (−0.011 to 0.123) | −0.291 (−0.393 to −0.191) | 0.344 (0.336 to 0.352) | |
| WS | 0.120 (0.051 to 0.189) | −0.550 (−0.657 to −0.445) | 0.367 (0.358 to 0.376) |
SNPs analyzed here are autosomal and non-CpG (a total of 7.54 million fully called SNPs). Values of Fay and Wu’s H were normalized as per Zeng et al.34 95% confidence intervals of each statistic were found by bootstrapping 10,000 random SNPs a total of 1,000 times.