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. 2014 Oct 1;9(1):538. doi: 10.1186/1556-276X-9-538

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Copyright © 2014 Busquets et al.; licensee Springer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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The bio-barcode amplification assay. The assay uses magnetic particles functionalized with monoclonal antibodies that recognize and bind ADDLs. The ADDLs are then sandwiched with a nanoparticle probe, modified with double-stranded DNA and an anti-ADDL polyclonal antibody. After repeated washing while using a magnet to immobilize the magnetic particles, a dehybridization step releases hundreds of barcode DNA strands for each antigen-binding event (From [39]. Copyright (2005) National Academy of Sciences, USA).