Table 1.

Cytokine analysis of lung homogenates in WT mice compared to STAT1 KO mice

Cytokine or Chemokine	Level (pg/ml) in pulmonary homogenate tissue at day:
	7		10
	WT	STAT 1 KO	WT	STAT 1 KO
Th1-type cytokine
IFN-γ	21.1 ± 3.89	12.48 ± 0.74*	20.48 ± 1.96	13.74 ± 0.79**
IL-2	32.57 ± 3.19	46.33 ± 3.47	23.34 ± 1.47	20.12 ± 1.39
IL-12 p40	81.27 ± 9.62	53.26 ± 12.15	227.46 ± 18.73	147.26 ± 18.48**
IL-12 p70	78.98 ± 12.20	88.52 ± 13.28	106.59 ± 15.52	153.50 ± 10.94*
Th2-type cytokine
IL-4	18.37 ± 5.98	41.31 ± 5.00*	10.01 ± 2.08	12.67 ± 1.58
IL-5	7.35 ± 1.02	18.02 ± 3.75	7.06 ± 0.85	8.14 ± 0.68
IL-10	31.75 ± 2.94	31.95 ± 1.74	48.52 ± 4.23	47.80 ± 2.81
IL-13	101.54 ± 14.09	106.21 ± 5.39	96.84 ± 8.14	109.80 ± 4.60
Pro-inflammatory cytokine
IL-1α	461.78 ± 114.37	310.38 ± 95.16	842.92 ± 185.14	1340.21 ± 153.47
IL-1β	2114.39 ± 549.41	2759.83 ± 845.82	3403.94 ± 654.74	5891.87 ± 611.89*
IL-6	112.10 ± 23.18	155.52 ± 59.42	72.76 ± 15.66	453.48 ± 86.54***
IL-17A	26.32 ± 3.63	240.85 ± 59.96***	20.15 ± 1.96	209.17 ± 33.27***
TNF-α	130.3 ± 21.03	157.33 ± 17.90	239.29 ± 59.03	458.83 ± 37.63*
G-CSF	348.32 ± 43.58	909.00 ± 281.48	294.15 ± 54.97	2709.22 ± 214.13**
GM-CSF	102.30 ± 8.10	103.72 ± 10.42	100.22 ± 3.59	129.84 ± 2.87
Chemokine
Eotaxin	719.54 ± 171.16	606.13 ± 87.17	647.81 ± 35.75	705.59 ± 32.28
CXCL1/KC	765.54 ± 109.51	955.89 ± 213.18	729.03 ± 141.35	1838.48 ± 178.00***
CCL5/RANTES	715.31 ± 160.53	212.17 ± 42.91***	1058.68 ± 110.91	132.78 ± 24.12***
CCL3/MIP-lα	770.42 ± 160.53	1114.23 ± 301.66	1215.11 ± 314.48	2080.93 ± 254.31
CCL4/MIP-1β	175.68 ± 41.64	157.79 ± 38.92	255.24 ± 43.82	305.41 ± 39.42
CCL2/MCP-1	924.17 ± 98.47	497.23 ± 98.31**	883.19 ± 146.02	1874.04 ± 192.94**

Data shown are expressed as mean ± SEM and are cumulative of 2 experiments utilizing 4 mice per group per time point.

^*p < 0.01,

^**p < 0.001,

^***p < 0.0001 compared to the infected counterpart on the same day postinoculation