Table 3.

Subgroup analysis comparing overweight (BMI 25-29.9 kg/m²) and obese (BMI ≥ 30 kg/m²) individuals in the weight-loss group.

	Obese (n=14)	Overweight (n=36)	Adjusted mean difference*	95% CI	P-value**
Global (All compartments)
Baseline Mean T2 (ms)	33.49 ± 3.74	32.53 ± 3.30	1.340	(−0.888, 3.568)	0.232
Change in Mean T2 (ms)	0.76 ± 1.90	1.92 ± 1.73	−1.841	(−2.981, −0.702)	0.002
Lateral Femoral Condyle
Baseline Mean T2 (ms)	34.49 ± 2.31	34.46 ± 2.43	0.085	(−1.459, 1.629)	0.912
Change in Mean T2 (ms)	1.04 ± 1.67	2.27 ± 2.65	−1.987	(−3.565, −0.409)	0.015
Lateral Tibia
Baseline Mean T2 (ms)	29.84 ± 2.39	29.86 ± 2.61	0.082	(−1.853, 2.016)	0.932
Change in Mean T2 (ms)	0.87 ± 1.83	0.70 ± 1.91	−0.281	(−1.679, 1.116)	0.687
Lateral Compartment
Baseline Mean T2 (ms)	32.27 ± 2.22	32.17 ± 2.16	0.024	(−1.457, 1.506)	0.974
Change in Mean T2 (ms)	0.98 ± 1.64	1.56 ± 2.16	−1.230	(−2.543, 0.083)	0.066
Medial Femoral Condyle
Baseline Mean T2 (ms)	39.03 ± 2.54	37.22 ± 2.43	1.571	(−0.152, 3.294)	0.073
Change in Mean T2 (ms)	−0.11 ± 2.08	1.11 ± 1.86	−1.678	(−3.096, −0.259)	0.022
Medial Tibia
Baseline Mean T2 (ms)	32.77 ± 2.90	31.72 ± 2.15	1.072	(−0.710, 2.853)	0.232
Change in Mean T2 (ms)	1.48 ± 3.54	1.16 ± 2.71	−0.997	(−3.099, 1.106)	0.344
Medial Compartment
Baseline Mean T2 (ms)	35.90 ± 2.46	33.63 ± 5.94	3.758	(0.108, 7.408)	0.044
Change in Mean T2 (ms)	0.68 ± 2.26	1.04 ± 1.79	−1.055	(−2.420, 0.309)	0.126
Patella
Baseline Mean T2 (ms)	34.67 ± 3.29	32.50 ± 2.91	2.406	(0.296, 4.515)	0.026
Change in Mean T2 (ms)	−0.12 ± 3.41	3.09 ± 2.53	−3.209	(−5.201, −1.217)	0.002

^*The associations between T2 parameters and baseline BMI of subjects in the weight-loss group were assessed using linear regression models (adjusted for age, gender, and baseline KL scores); reported values represent absolute differences in T2 values.

^**P-value adjusted for age, gender, and baseline KL score. P-values <0.05 are in bold.