Mean fluorescent staining intensity (MFI) of (A) ANA (B) GN in 6 month old tm or tm24KO mice categorized as clinical score 1–5 for disease severity (5 is sever disease). (C) Quantification of H&E number of nuclei per glomeruli (20X). Data are representative of one pair of 5 or more pairs of mice, (*=p<.05). (C) Serum level of IgM, IgA, IgG1, IgG3, IgG2b, IgG2c are averages of 5 pairs of mice, (*=p<.05).