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Specific deletion of Baf250a in the SAN caused sinus bradycardia. (A) Expression of Baf250a in the SAN. Double-label fluorescent immnohistochemistry at postnatal day 21 (P21) to show expression of Hcn4 (red) and Baf250a (green). Scale bar, 100 μm. (B) Representative surface EKG tracing in lead II. (C) EKG parameters of littermate control and Baf250a CKO at P21. Bpm, beats per minute; msec, milliseconds; QTc, corrected QT interval.
