Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug 22;24(10):1201–1213. doi: 10.1038/cr.2014.113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0

PMC Copyright notice

A working model of Baf250a in maintaining identity of SAN. The transcriptional hierarchy starts with Baf250a, which activates the expression of Tbx3. Baf250a, Tbx3, and HDAC3 act combinatorially to repress the expression of Nkx2.5 through histone deacetylation in the SAN. Increased expression of Nkx2.5 after deletion of Baf250a in the SAN subsequently activates the expression of Gata4 and Tbx5 in a self-reinforcing manner. Nkx2.5, Tbx5, and Gata4 eventually activate a contractile cardiomyocyte program including enhanced expression of Kcnj2 in the SAN, which negatively affects pacemaking activity of the SAN.