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. 2014 Sep 3;3(9):e63. doi: 10.1038/emi.2014.62

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The EBV LMP1 oncoprotein and its lytic variant lyLMP1. (A) Functional domains and motifs are indicated for EBV LMP1 and lyLMP1 in the B95-8 EBV isolate. (B) EBV LMP1 ORF and lyLMP1 are produced by RNA splicing (dashed lines) from two separate transcripts derived either from the ED-L1 promoter or the ED-L1A promoter. Nucleotide positions are numbered according to the genomic DNA sequence of the B95-8 EBV isolate (GenBank: V01555.2). TRAF, TNF receptor-associated factor; TRADD, tumor necrosis factor receptor associated death domain protein.