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. 2014 May 24;130(4):555–562. doi: 10.1111/jnc.12744

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© 2014 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig 3 — Peptidylarginine deiminase (PAD) inhibition reduces neuronal damage in neonatal hypoxic ischaemic (HI) with 60-min (strong) hypoxia. Following HI with strong (60 min) hypoxia, severe tissue loss (a), strong microglial activation with phagocytic morphology (b) and TUNEL-positive cells (c) were observed in the hippocampus after 48 h. Upon treatment with one dose of Cl-amidine (CA; 60 mg/kg) immediately following hypoxia, reduced damage was seen in the hippocampus (d) and a significant difference was observed both in the level of microglial activation (e) and TUNEL-positive cells (f). Scale bars: a & d = 500 μM; b, c, e, f = 200 μM. For reference, the regions of the hippocampus (dentate gyrus (dg) and CA 1, 2, 3) are indicated in f.