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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Glaucoma. 2014 Oct-Nov:S55–S58. doi: 10.1097/IJG.0000000000000127

Figure 2. The proposed mechanism of TGF-β2 regulation of LOX and LOXL 1 in the trabecular meshwork.

Figure 2

Elevated levels of TGF-β2 in the glaucomatous trabecular meshwork (TM), increases the expression and secretion of LOX, LOXL 1 and BMP-1. Increased Localized levels of BMP-1 would result in increased cleavage of precursor forms of LOX and LOXL 1 resulting in increased levels of enzymatically active LOX and LOXL 1 molecules. Subsequent cross-linking of collagen and/or elastic fibers in the TM may increase localized stiffness, aqueous humor outflow resistance and elevate intraocular pressure.