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. Author manuscript; available in PMC: 2015 Apr 3.
Published in final edited form as: Nat Commun. 2014 Oct 3;5:4904. doi: 10.1038/ncomms5904

Fig. 5. CendR peptide initiates an NRP1-dependent endocytosis process resembling macropinocytosis.

Fig. 5

(A) PPC1 cells were cultured in complete, AA-free or glucose-free media for 16 h followed by the incubation with R-Au (dense dots, 50 nm) for 30 min and fixation. Representative TEM images at cell-entry sites are shown.

(B) Representative TEM images for intracellular organelles containing R-Au (50 nm) with characteristics of endosome and MVB.

(C) NRP1 dependence of CendR endocytosis. HeLa cells without or with transfection of NRP1 expression plasmids (NRP1 WT or ΔSEA) were incubated with R-Au (dense dots, 50 nm) for 30 min before fixation. Representative TEM images are shown. Scale bar, 200 nm.