Figure 3. Contrasting TCR-epitope networks of “classic” T-cell epitopes from pH1N1 and H7N9 HA. Human genome T-cell epitope conservation defined by JanusMatrix⁵³ is illustrated using Cytoscape. Here, the more limited human conservation of TCR-facing residues for the T-cell epitope in Influenza A/H1N1 2009/CA (pH1N1; three 9-mers, with 0, 2, or 8 human conserved epitopes), contrasts with a similar epitope in H7N9 (three 9-mers, with 9, 13, or 2 human conserved epitopes). A detailed description of the JanusMatrix tool is available in reference 53.