Table 1. hSBA Geometric mean titers in all study groups, and ratios of GMTs between 4CMenB groups.
| Study groups | Ratio of GMTs 4CMenB+Para and 4CMenB (95% CI) |
||||
|---|---|---|---|---|---|
| Antigen | Time-point | 4CMenB | 4CMenB + Para | Men C | |
| fHbp | Pre-vaccination |
1.25 (1.14–1.37) n = 166 |
1.18 (1.08–1.3) n = 166 |
1.16 (1.09–1.25) n = 168 |
0.95 (0.84–1.07) |
| Post-3rd dose |
101 (90–113) n = 170 |
102 (91–115) n = 167 |
1.24 (1.11–1.39) n = 132 |
1.02 (0.87–1.18) | |
| Pre-booster |
4.94 (3.76–6.5) n = 69 |
4.51 (3.43–5.95) n = 70 |
1.15 (1.03–1.29) n = 74 |
0.91 (0.63–1.32) | |
| Post-booster |
120 (95–150) n = 65 |
136 (107–172) n = 63 |
12 (10–16) n = 75 |
1.13 (0.83–1.55) | |
| NadA | Pre-vaccination |
1.18 (1.07–1.3) n = 162 |
1.07 (0.97–1.18) n = 157 |
1.21 (1.09–1.34) n = 161 |
0.91 (0.8–1.04) |
| Post-3rd dose |
396 (348–450) n = 165 |
455 (399–519) n = 160 |
1.15 (1.03–1.29) n = 159 |
1.15 (0.96–1.37) | |
| Pre-booster |
69 (53–88) n = 71 |
106 (82–136) n = 71 |
1.11 (0.95–1.29) n = 70 |
1.55 (1.1–2.16) | |
| Post-booster |
1950 (1573–2417) n = 73 |
2182 (1769–2691) n = 76 |
41 (29–57) n = 69 |
1.12 (0.85–1.48) | |
| NZOMV | Pre-vaccination |
1.02 (0.99–1.06) n = 170 |
1.02 (0.99–1.05) n = 169 |
1.06 (1–1.13) n = 171 |
0.99 (0.95–1.04) |
| Post-3rd dose |
10 (8.59–12) n = 171 |
8.48 (7.24–9.93) n = 168 |
1.05 (1.01–1.1) n = 168 |
0.85 (0.68–1.05) | |
| Pre-booster |
1.6 (1.43–1.8) n = 141 |
1.48 (1.32–1.66) n = 143 |
1.03 (1–1.06) n = 148 |
0.92 (0.79–1.08) | |
| Post-booster |
20 (16–24) n = 138 |
20 (17–25) n = 140 |
2.2 (1.89–2.57) n = 147 |
1.02 (0.78–1.33) | |