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Necrosis/apoptosis in IR livers following activation/inhibition of cAMP-PKA (6h of reperfusion after 90min of ischemia). (a) and (b) TUNEL-assisted detection of hepatic necrosis/apoptosis (dark arrows) in ischemic liver lobes (magnification x400); (c) caspase-3 activity levels; (d) Western blot-assisted detection of p-CREB protein (1 h of reperfusion), anti-necrosis/apoptotic Bcl-2 and Bcl-xl protein; p-IκBα, and p-NF-κB levels (6h of reperfusion). (**p<0.01, *p<0.001, n=6-8/group).
