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The functional significance of IL-10 in liver cytoprotection following activation of cAMP-PKA pathway. Adjunctive neutralization of IL-10 prior to the onset of ischemia restored liver injury in Forskolin (PKA activator)-pretreated mice, as evidenced by (a) sALT levels (*p<0.001, n=6/group); (b) liver histology (representative H&E staining; magnification x100 and x400); and (c) CXCL-10, TNF-α, and IL-1β gene expression pattern (*p<0.001).
