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. 2014 Oct 6;5:386. doi: 10.3389/fphys.2014.00386

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Copyright © 2014 Huysseune, Soenens and Elderweirdt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dentition in mbl and apc mutant zebrafish. Dentition in WT (A) and mbl mutants (B) at 5dpf, and WT (C) and apc mutants (D) at 3 dpf. Insets: WT (A) and mbl mutant (B) at 6 dpf, and WT (C) and apc mutant (D) at 2 dpf. Color codes for arrowheads as in Figure 3. Note the complete similarity in tooth pattern between 5 dpf WT (A) and mbl mutants (B), and the substantial developmental delay in 3 dpf apc mutants (D) compared to WT fish (C), as can be observed from the large amount of yolk (y) still present, the thin endodermal layer covering the yolk (black arrowhead), and the absence of cartilage in the neurocranial base flanking the notochord (nc). Ov, otic vesicle. Note that sections are slightly oblique and different sets of teeth are visible on either body side. Scale bars = 50 μm.