Table I.
Characteristics of the included trials.
Patients (n) | Intervention | |||||
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Study | Experimental | Control | Experimental | Control | Duration (weeks) | Outcomes |
Brandt et al 2003 (26) | 14 | 16 | ETN | PBO | 6 | ASAS 20, ASAS 50, BASDAI, BASDAI 50, BASFI, AEs |
Calin et al 2004 (24) | 45 | 39 | ETN | PBO | 8 | ASAS 20, ASAS 50, ASAS 70, AEs |
Davis Jr et al 2003 (22) | 138 | 139 | ETN | PBO | 24 | ASAS PR, BASDAI, BASFI, OW, CRP, AEs |
Gorman et al 2002 (21) | 20 | 20 | ETN | PBO | 16 | OW, AEs |
Deng et al 2009 (29) | 26 | 26 | ETN | PBO | 6 | ASAS 20, ASAS 50, ASAS 70, BASDAI 50, AEs |
Dougados et al 2011 (19) | 39 | 43 | ETN | PBO | 12 | BASDAI, BASDAI 50, BASFI, ASAS PR, CRP, AEs |
van der Heijde et al 2006 (25) | 150 | 51 | ETN | PBO | 12 | BASDAI 50, ASAS PR, AEs |
Huang et al 2010 (28) | 74 | 78 | ETN | PBO | 6 | ASAS 20, ASAS 50, ASAS 70, BASDAI, BASFI, AEs |
Huang et al 2011 (27) | 300 | 100 | ETN | PBO | 6 | ASAS 20, BASDAI 50, ASAS PR, AEs |
Lin et al 2010 (20) | 19 | 20 | ETN | PBO | 6 | ASAS 20, ASAS 50, ASAS 70 |
Zhang et al 2009 (30) | 43 | 43 | ETN | PBO | 6 | ASAS 20, ASAS 50, ASAS 70, BASDAI 50, ASAS PR |
Braun et al 2011 (23) | 378 | 187 | ETN | SSZ | 16 | ASAS 20, BASFI, ST, CRP, AEs |
Chen et al 2010 (35) | 20 | 20 | ETN | SSZ | 12 | ST |
Zhao et al 2009 (31) | 30 | 30 | ETN | SSZ | 6 | ASAS 20, BASDAI, ST, ESR, CRP, AEs |
Zhao et al 2009 (32) | 43 | 43 | ETN | SSZ | 12 | BASDAI, BASFI, ESR, CRP, AEs |
ETN, etanercept; PBO, placebo; SSZ, sulfasalazine; ASAS, assessment in ankylosing spondylitis; BASDAI, Bath ankylosing spondylitis disease activity index; BASFI, Bath ankylosing spondylitis functional index; AE, adverse effect; OW, occiput-to-wall; ST, Schober’s test; PR, partial remission; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.