Table 1.
The HLA-G exons and introns, their size, function, and nomenclature.
| According to NC_000006.12 (hg19) | According to IMGT/HLA | Size (nt) | Function considering the full-length mRNA |
|---|---|---|---|
| Exon 1 | – | 66 | 5′UTR |
| Intron 1 | – | 688 | Spliced out |
| Exon 2 | Exon 1 | 185 | 5′UTR/Leader peptide |
| Intron 2 | Intron 1 | 129 | Spliced out |
| Exon 3 | Exon 2 | 270 | Alpha-1 domain |
| Intron 3 | Intron 2 | 226 | Spliced out |
| Exon 4 | Exon 3 | 276 | Alpha-2 domain |
| Intron 4 | Intron 3 | 599 | Spliced out |
| Exon 5 | Exon 4 | 276 | Alpha-3 domain |
| Intron 5 | Intron 4 | 122 | Spliced out |
| Exon 6 | Exon 5 | 117 | Transmembrane domain/cytoplasmic tail |
| Intron 6 | Intron 5 | 445 | Spliced out |
| Exon 7 | Exon 6 | 33 | Cytoplasmic tail/stop codon/3′UTR |
| Intron 7 | – | 357 | Spliced out |
| Exon 8 | – | 355 | 3′UTR |