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. 2014 Jan 26;2(1):2. doi: 10.1002/prp2.18

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© 2014 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Regulation of the transcriptional activity of hPXR by NJ. HepG2 cells were transfected with an expression vector for GAL4/DBD-hPXR/LBD (0.05 μg) together with the pG5luc (0.1 μg) and pGL4.74 (0.01 μg) plasmids. The transfected cells were treated with the solvent control (0.1% DMSO) or increasing concentrations of NJ (0.01, 0.1, 0.5, 1, 5, 10, 25 μmol/L) or positive control [Rifampicin (Rif, 10 μmol/L)]. After 24 h, luciferase activity was measured using the Dual-Luciferase Reporter Assay System. Results are expressed as fold activation over the solvent control (mean ± SD, n = 4); **P < 0.01.