Table 6.
Summary of the pharmacokinetic parameters for XG-102 following single intravenous doses administered as a constant rate infusion over 1 h
| XG-102 dose | 10 μg/kg | 40 μg/kg | 80 μg/kg |
|---|---|---|---|
| Number of subjects | 6 | 6 | 6 |
| Parameter | |||
| AUC0–last (ng h/mL) | 24.7 (20.0–30.5) | 134 (118–152) | 431 (312–596) |
| AUC0–∞ (ng h/mL) | 36.8 (30.5–44.6) | 146 (126–168) | 443 (320–612) |
| AUCextrap1 (%) | 34.1 (18.6–49.7) | 6.7 (4.2–12.9) | 2.9 (1.9–3.4) |
| Cmax (ng/mL) | 31.3 (25.7–38.2) | 146 (128–168) | 362 (274–479) |
| tmax1(h) | 1.00 (1.00–1.05) | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) |
| MRT (h) | 1.00 (0.79–1.27) | 0.76 (0.70–0.84) | 1.02 (0.91–1.15) |
| t½ (h) | 0.57 (0.40–0.81) | 0.36 (0.30–0.43) | 0.65 (0.48–0.89) |
| CL (mL/h) | 17537 (14441–21297) | 18399 (16092–21037) | 13217 (9381–18621) |
| CL (mL/h/kg) | 217 (177.3–264.8) | 253 (222.1–287.4) | 165 (118.4–229.1) |
| Vss (mL) | 17536 (13078–23513) | 14040 (12346–15967) | 13500 (10564–17251) |
| Vss (mL/kg) | 217 (174–271) | 193 (172–216) | 168 (132–214) |
Geometric mean (90% confidence limits) data are presented.
1
Median (minimum–maximum).