Table 7.
Evaluation of XG-102 pharmacokinetic parameters dose proportionality following single intravenous doses administered as a constant rate infusion over 1 h
| XG-102 dose | 10 μg/kg | 40 μg/kg | 80 μg/kg |
|---|---|---|---|
| Number of subjects | 6 | 6 | 6 |
| Parameter | |||
| AUC0–last(norm) (ng h/mL)/(μg/kg) | 3.10 (2.44–3.92) | 3.64 (3.25–4.08) | 5.91 (4.25–8.22) |
| AUC0–∞(norm) (ng.h/mL)/(μg/kg) | 4.61 (3.78–5.64) | 3.96 (3.48–4.50) | 6.07 (4.36–8.44) |
| Cmax(norm) (ng/mL)/(μg/kg) | 3.93 (3.13–4.92) | 3.98 (3.49–4.53) | 4.97 (3.74–6.60) |
Geometric mean (90% CI) data are presented. (norm) = normalized for dose and body weight.