Table 1.

Individual metabolic clearance values for dronedarone and its metabolites in each of the different cryopreserved human hepatocyte preparations

	In vitro intrinsic hepatic clearance (mL·h−1·106 cells)
Drug	BD-91	BD-296	HU-1359	IVT-IBG	Mean ± SD
Dronedarone	0.49	0.58	0.14	0.10	0.33 ± 0.21
N-debutyl-dronedarone	0.18	0.10	0.10	0.08	0.13 ± 0.03
Propanoic acid-dronedarone	0.06	0.17	0.20	0.14	0.14 ± 0.05
Phenol-dronedarone	0.44	0.70	0.57	0.75	0.62 ± 0.12
C-dealkyl-dronedarone	0.003	0.002	0.004	0.003	0.003 ± 0.001