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The in vitro antiproliferative activity of HES–MTX conjugates in comparison with free MTX
| Cell line, IC50 ± SD (nmol L−1)1 | ||
|---|---|---|
| Compound | MV4-11 | P388 |
| HES-MTX | 106 ± 27 | 196 ± 32 |
| MTX | 10.4 ± 3.1 | 15.1 ± 1.1 |
The compounds were tested in concentrations ranging from 2 to 2000 nmol L−1 for HES-MTX (MTX-equiv) and 0.2 to 200 nmol L−1 for MTX.
