Figure 1.

Dose- and time-dependent bronchoprotection against ACh-induced bronchoconstriction by GS-5759 in Dunkin–Hartley guinea pigs. ACh challenges were performed at 24 h before compound treatment and 4, 8, and 24 h post compound treatment. Data represent the mean ± SEM of the percentage inhibition of bronchoconstriction as measured by PenH compared to a precompound dosing level elicited by the same dose of ACh, with each animal acting as its own control (n = 6 animals per dose-group), *P < 0.05, **P < 0.01 compared to vehicle treatment. IND, indacaterol.