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. 2014 Jun 9;2(4):e00046. doi: 10.1002/prp2.46

Figure 2.

Figure 2

Dose-related inhibition of neutrophil recruitment and proinflammatory cytokine production by GS-5759 in the BAL of LPS-exposed Lewis rats. (A) Data represent the mean ± SEM of the percent maximum inhibition of neutrophils in BAL fluid compared to vehicle-treated animals 4 h post-LPS aerosol exposure for n = 5–18 animals per group. (B) Data represent the mean ± SEM of proinflammatory cytokines in BAL fluid 2 h post-LPS aerosol exposure for n = 6 animals per group. Open bars represent oral vehicle, black bars represent roflumilast (10 mg/kg, oral), shaded bars represent intratracheal vehicle and hatched bars represent GS-5759 (300 μg/kg, IT). *P < 0.05, **P < 0.01, ***P < 0.001 compared to vehicle-treated animals dosed via the same route of administration. GSK is GSK256066, IND, indacaterol; ROF, roflumilast.