Table 2.
Cardiac mass and function in TRPA1 WT and KO mice following 14-day infusion of angiotensin II
| 14-day angiotensin II | ||
|---|---|---|
| TRPA1 WT | TRPA1 KO | |
| HW:BW | 5.61 ± 0.21* | 6.19 ± 0.23* |
| (mg) | N = 18 | N = 22 |
| LV:BW | 5.26 ± 0.19 | 5.79 ± 0.38* |
| (mg g−1) | N = 10 | N = 13 |
| (echocardiography) | ||
| Cardiac output | 14.47 ± 1.47 | 13.25 ± 0.92 |
| (mL min−1) | N = 8 | N = 10 |
| Stroke volume | 30.35 ± 2.44 | 26.16 ± 1.80 |
| (μL) | N = 7 | N = 10 |
| Ejection fraction | 54.06 ± 2.28 | 60.48 ± 3.53 |
| (%) | N = 8 | N = 10 |
| Fractional shortening | 27.44 ± 1.45 | 32.07 ± 2.75 |
| (%) | N = 8 | N = 10 |
Heart weight (HW) and body weight (BW) were calculated at necropsy. All other measures were collected using in vivo echocardiography, including left ventricular mass (LV). N as indicated, data shown ± SEM.
*
P < 0.05 compared to previously quoted basal values (Table 1) using a two-way ANOVA with Sidak’s post hoc test.