Figure 1.

Effects of myocardial infarction (MI) induced by ligation of left anterior descending (LAD) artery in mice. (A) Left ventricular (LV) ejection fraction and (B) fractional shortening decreased significantly postinfarction. (C) MI increased the fibrotic area in the LV. (D) Number of DDR2⁺ and (E) FAP⁺ cells were significantly elevated at 3 and 5 days postinfarction. (F) MI resulted an increase in DDR2 mRNA levels at 4 weeks postinfarction. (G) Let-7c miRNA levels were significantly decreased in LV 5 days after MI. Results are mean ± SEM. (A–C) n = 8–11, (D, E, G) n = 3–6, (F) n = 6–9. White column: sham-operated; black column: MI. Data were analyzed with Student’s t-test. *P < 0.05, **P < 0.01, and ***P < 0.001 versus sham. DDR2, discoidin domain receptor 2; FAP, fibroblast activation protein; Let-7c, lethal-7c.