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. 2014 Jun 12;2(4):e00056. doi: 10.1002/prp2.56

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© 2014 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Let-7c inhibition prevented the deterioration of systolic function after MI. (A) Representative images from echocardiography M-mode view. (B, C) Let-7c inhibitor maintained LV ejection fraction postinfarction. (D) There was a tendency for stroke volume to increase in response to Let-7c inhibitor. (E) Let-7c inhibitor enhanced cardiac output 4 weeks after MI. (F, G) Let-7c inhibitor had no effect on the LV posterior wall thickness in systole (LVPW;s) or diastole (LVPW;d). Results are mean ± SEM. (B–G) n = 7–8. Data were analyzed with ANOVA. *P < 0.05 versus scramble. Let-7c, lethal-7c; MI, myocardial infarction; LV, left ventricular.