Table 10.

Dose–response relations and corresponding ED₅₀s for various effects observed over a 4-h period after challenge with RO-4-1284 (10 mg/kg, s.c.) in rats that received test compound simultaneously with RO-4-1284

Effect		Dose of SKF-82958 (mg/kg, s.c.)							ED50
Time (h)	Criterion	0.04	0.08	0.16	0.31	0.63	1.25	2.51	(95% CL; mg/kg)
Reversal of sedation/passivity
1	Absence (6.0%)2	2	1	0	2	3	0	0/4	>2.5
2	Absence (4.0%)2	1	0	0	2	3	0	0/4	>2.5
3	Absence (2.0%)2	1	0	0	1	2	0	0/4	>2.5
4	Absence (16%)2	0	0	0	0	1	0	1/4	>2.5
Reversal of catalepsy
2	Score <2 (0.0%)2	0	1	0	1	1	0	3/4	2.1 (–)
3	Score <5 (2.0%)2	1	1	1	1	2	1	2/4	2.5 (–)
4	Score <5 (8.0%)2	0	1	0	1	1	1	1/4
Induction of excitation
1	Presence (0.0%)2	0	0	0	0	0	0	0/4	>2.5
2	Presence (0.0%)2	0	0	0	0	0	0	0/4	>2.5
3	Presence (0.0%)2	0	0	0	0	0	0	0/4	>2.5
4	Presence (0.0%)2	0	0	0	0	0	0	0/4	>2.5

The number of rats responding to the listed criterion is listed per dose level (n = 5 per dose group). Values representing more than 50% responders are formatted bold.

¹One of the five rats tested at 2.5 mg/kg died and was not included.

²Percentage of false positives (solvent-pretreated rats responding to the criterion [n = 50]).