Table 12.
ED50s (95% confidence limits) for inhibition of d-amphetamine-induced hyperlocomotion and for reversal of hypolocomotion induced by the D1 antagonist SCH-23390, the monoamines-depleting agent RO-4-1284, or the D2 antagonist haloperidol measured in mice 0.5 h after s.c. injection
| ED50s (95% confidence limits; mg/kg, s.c., −0.5 h) | ||||
|---|---|---|---|---|
| Compound | d-Amphetamine (<5500 cm) | SCH-23390 (>2500 cm) | RO-4-1284 (>2500 cm) | Haloperidol (>2500 cm) |
| JNJ-42314415 | 8.1 (5.4–12.2) | 7.1 (4.8–10.7) | 2.69 (1.99–3.6) | >401 |
| PQ-10 | 12.4 (9.1–16.7) | 16.3 (10.1–26.3) | 5.4 (–) | >40 |
| MP-10 | 1.78 (1.10–2.87) | 1.17 (0.86–1.58) | 0.58 (0.34–1.01) | >40 |
| TP-10 | 1.78 (1.19–2.66) | 1.78 (1.18–2.65) | No stock | >10 |
| Haloperidol | 0.112 (0.075–0.168) | – | – | – |
| SKF-82958 | – | 0.148 (0.109–0.200) | 0.294 (0.218–0.40) | >10 |
1
60% responders at 10 mg/kg.