Table 2.
Inhibition of apomorphine-induced agitation in rats: nonlinear regression estimates for the time and dose of peak effect, and for the onset and duration of action after s.c. dosing
| Peak effect | ||||||
|---|---|---|---|---|---|---|
| Compound | Time (h) | ED50 (mg/kg) | Onset1 (h) | Duration1 (h) | R2 | Sy.x |
| JNJ-42314415 | 0.5 | 0.95 | <0.5 | 4.3 | 0.985 | 0.068 |
| PQ-10 | 0.83 | 3.5 | <0.5 | 4.8 | 0.930 | 0.163 |
| TP-10 | 0.68 | 1.07 | <0.5 | 4.3 | 0.995 | 0.044 |
| MP-10 | 0.77 | 0.88 | <0.5 | 2.8 | 0.929 | 0.217 |
The values were interpolated from the nonlinear regression lines in Figure 1. Values for R2 and Sy.x show the goodness of fit of the nonlinear regression lines.
1
Onset and duration of action were assessed at four times the peak-effect dose.