Table 3.
ED50s (and 95% confidence limits) for induction of slight and pronounced catalepsy, the subsequent disappearance of catalepsy, and the induction of agitation in rats cotreated with SCH-23390 (0.63 mg/kg, s.c.)
| ED50s (95% confidence limits; mg/kg, s.c.) | ||||
|---|---|---|---|---|
| Induction of catalepsy | ||||
| Time (h) | Slight (score >2) | Pronounced (score = 6) | Disappearance of slight catalepsy (score ≤2) | Induction of agitation |
| JNJ-42314415 | ||||
| 1 | 1.54 (1.14–2.09) | 1.54 (1.14–2.09) | 10.8 (8.0–14.6) | 10.8 (8.0–14.6) |
| 2 | 1.54 (1.14–2.09) | 1.77 (1.44–2.18) | 10.8 (8.0–14.6) | 12.4 (9.1–16.7) |
| 3 | 2.03 (1.50–2.75) | 2.04 (1.51–2.76) | 16.3 (12.0–22.1) | 21.5 (13.3–35) |
| 4 | 3.5 (2.87–4.4) | 3.6 (2.88–4.4) | 16.3 (12.0–22.1) | >40 |
| PQ-10 | ||||
| 1 | 3.6 (2.37–5.3) | 4.7 (3.4–6.3) | 32 (21.7–49) | >40 |
| 2 | 5.4 (4.0–7.3) | 5.4 (4.0–7.3) | 43 (–) | >40 |
| 3 | 8.2 (6.0–11) | 10.8 (8.0–14.6) | 43 (–) | >40 |
| 4 | 18.7 (13.8–25.3) | 21.5 (15.9–29.1) | >40 | >40 |
| MP-10 | ||||
| 1 | 0.294 (0.182–0.48) | 0.44 (0.297–0.67) | 4.1 (2.73–6.1) | 5.4 (3.6–8.1) |
| 2 | 0.44 (0.276–0.72) | 0.51 (0.32–0.82) | 7.1 (4.7–10.6) | 7.1 (4.7–10.6) |
| 3 | 0.77 (0.57–1.05) | 1.78 (1.18–2.65) | 14.2 (11.5–17.4) | 21 (–) |
| 4 | 2.69 (1.80–4.0) | 3.1 (2.28–4.2) | 18.7 (13.8–25.3) | >20 |