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. 2014 Aug 24;2(6):e00066. doi: 10.1002/prp2.66

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© 2014 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Mefloquine has cytotoxic activity on mast cells. (A) Concentration response of the effect of mefloquine on murine bone marrow-derived mast cells (BMMCs) (WT, serglycin−/− and mMCP-6−/−), peritoneal cell-derived mast cells (PCMCs), human cord blood-derived mast cells (CBMCs) and human mast cell line-1 (HMC-1). Cell viability was measured after 24 h of treatment. (B) Time course of mefloquine-induced cell death. BMMCs (WT, serglycin−/− or mMCP-6−/−) were treated with 10 μmol/L mefloquine and cell viability was determined at the indicated time points. Results are expressed as % cell survival (mean ± SEM, n = 3) in comparison with nontreated control cells.