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. 2014 Aug 24;2(6):e00066. doi: 10.1002/prp2.66

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© 2014 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Mefloquine-induced cell death in bone marrow-derived mast cells (BMMCs) is caspase-independent. BMMCs (0.5 × 10⁶ cells) were preincubated with or without a panel of inhibitors 30 min before addition of mefloquine. After 8 h incubation with 20 μmol/L of mefloquine, cell viability assessment was performed. Data are displayed as mean ± SEM (n = 3). ***P < 0.0001; UNT, untreated; MQ, mefloquine; PesA, pepstatin A; Pef, Pefabloc SC; MQ, mefloquine. Inhibitors were used at the following concentrations: E-64d (20 μmol/L), Z-DEVD-FMK (20 μmol/L), Z-VAD-FMK (20 μmol/L), Pepstatin A (50 μmol/L) and Pefabloc SC (0.1 mmol/L).