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. 2014 Sep 1;2(6):e00081. doi: 10.1002/prp2.81

Figure 2.

Figure 2

AZD5582 does not sensitise CLL cells to killing by fludarabine or dexamethasone. (A) Available CLL samples from among the cases shown in Figure 1A were incubated for 48 h with 1 nmol/L AZD5582 and/or fludarabine (F) at the indicated concentrations. Cell death was measured as in Figure 1C. (B) CLL cells were incubated for 48 h with 1, 10 or 100 nmol/L AZD5582 and/or fludarabine (F) at the indicated concentrations and cell death measured as above. (C) CLL cells were incubated for 48 h with AZD5582 at the indicated concentrations before analysing for levels of IAP proteins by Western blotting as in Figure 1A. The numbers under the lanes refer to the ratio of the respective IAP protein relative to β-actin, normalised to that of untreated cells in each sample. (D) CLL cells were incubated for 48 h with either 1 nmol/L AZD5582 and/or dexamethasone (D) at the indicated concentrations and cell death measured as above.