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. 2014 Sep 1;2(6):e00081. doi: 10.1002/prp2.81

Figure 3.

Figure 3

AZD5582 sensitises CLL cells to killing by TRAIL. (A) CLL cells were incubated with 1 nmol/L AZD5582 and/or TRAIL at the indicated concentrations and cell death was measured as in Figure 1C. A representative series of flow cytometry dot-plots is shown. Live cells are annexin/PI dim, early apoptotic cells are annexin bright/PI dim and late apoptotic/necrotic cells are annexin/PI bright. (B) CLL samples with or without 17p or 11q deletions were incubated for 24 and 48 h with 1 nmol/L AZD5582 and/or TRAIL at the indicated concentrations (100 or 500 ng/mL) and cell death measured as described above.