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Substrate specificity of NA-VLPs. N1 from H5N1 was incubated with either α-2,3- or α-2,6-sialyllactose. The cleavage (A) and the binding (B) of the NA were monitored by 1H and STD-NMR, respectively. Panel B shows the N1av, but comparable data were obtained for N1sea and N1pdm (data not shown).
