Table III.

Concentration of MIF in pre- and postoperative serum and saliva in patients with oral squamous cell carcinoma and its association with clinicopathological variables.

		Preoperative serum MIF (ng/ml)				Postoperative serum MIF (ng/ml)				Preoperative saliva MIF (ng/ml)				Postoperative saliva MIF (ng/ml)
Variable	n	Range	Median	P-value	n	Range	Median	P-value	n	Range	Median	P-value	n	Range	Median	P-value
Age (years)				0.051				0.826				0.992				0.594
≤56.5	25	17.7–95.5	44.0		21	15.2–78.1	33.2		25	32.5–1013.2	348.5		20	64.5–2046.8	270.0
>56.5	25	20.9–136.6	59.1		17	16.2–118.5	34.2		23	67.6–1770.6	309.4		15	122.1–1015.5	244.0
Smoking status				0.711				0.216				0.072				0.040
Current	42	17.7–136.6	51.7		34	15.1–118.5	32.7		40	32.5–1770.6	228.8		29	64.5–2046.8	244.0
Ex-smoker	8	25.8–76.2	49.8		4	32.4–45.6	40.9		8	82.6–1059.1	466.5		6	221.8–1015.5	373.6
Alcohol consumption				0.630				0.263				0.587				0.919
Current	29	17.7–104.6	50.1		24	15.1–118.5	31.6		28	32.5–1490.2	216.2		21	64.5–1015.5	261.4
Never or ex-drinker	21	17.7–136.6	56.9		14	20.5–78.1	35.2		20	42.7–1770.6	383.6		14	106.5–2046.8	238.6
pT stage				0.184				0.619				0.001				0.091
pT1 + pT2	25	17.7–136.6	57.0		18	16.2–118.5	35.8		24	45.6–867.6	165.9		19	79.7–878.6	215.8
pT3 + pT4	25	17.7–95.0	48.3		20	15.1–78.1	32.8		24	32.5–1770.6	445.8		16	64.5–2046.8	314.7
Lymph node status (pN)				0.018				0.362				0.317				0.570
pN0	30	20.9–136.6	56.9		23	16.2–118.5	36.3		29	42.7–1490.2	255.5		24	79.7–1015.5	261.4
pN+	20	17.7–104.6	37.8		15	15.1–74.8	32.3		19	32.5–1770.6	474.2		11	64.5–2046.8	250.9
Pathological staging				0.040				0.380				0.032				0.479
GI + GII	17	20.9–136.6	59.6		13	16.2–118.5	36.9		17	45.6–461.8	172.6		14	79.7–878.6	229.9
GIII + GIV	33	17.7–104.6	48.3		25	15.1–78.1	32.4		31	32.5–1770.6	417.4		21	64.5–2046.8	261.6
Differentiation grade				0.618a				0.997a				0.938a				0.883a
Poor	2	17.7–104.6	61.2		2	28.1–41.5	34.8		2	67.6–960.3	514.0		2	122.1–2046.8	1084.5
Moderate	38	20.3–136.6	51.7		31	15.1–118.5	34.2		36	32.5–1059.1	320.8		27	64.5–1015.5	261.4
Well	10	17.7–79.1	44.3		5	18.3–51.0	32.3		10	82.6–1770.6	254.9		6	106.5–832.8	261.6
Blood vessel invasion				0.562				NE				0.700				0.815
Not detected	45	17.7–129.5	48.6		34	15.1–118.5	32.3		43	32.5–1770.6	255.5		30	64.5–2046.8	261.5
Detected	2	56.9–59.6	58.2		1	78.1	78.1		2	348.5–406.2	377.4		2	221.8–261.4	241.6
Lymphatic invasion				0.960				0.724				0.653				0.079
Not detected	36	17.7–129.5	49.8		27	15.1–118.5	32.4		34	42.7–1490.2	252.1		25	79.7–2046.8	272.8
Detected	11	22.8–104.6	48.6		8	23.2–78.1	33.4		11	32.5–1770.6	406.2		7	64.5–278.4	221.8
Perineural invasion				0.714				0.711				0.818				0.258
Not detected	27	17.7–129.5	49.5		21	15.1–118.5	32.4		26	49.1–1059.1	252.1		21	112.8–2046.8	261.4
Detected	20	22.8–95.0	49.9		14	19.9–78.1	33.4		19	32.5–1770.6	406.2		11	64.5–832.8	261.4
Inflammatory infiltrate				0.510				0.338				0.988				0.872
Poor	12	17.7–95.0	44.0		8	15.1–55.3	31.2		11	42.7–1770.6	176.9		6	79.7–2046.8	275.4
Moderate + intense	29	20.3–129.5	49.5		24	16.2–118.5	33.9		29	32.5–1490.2	332.2		23	64.5–1011.9	261.4
Surgical margin status				0.355				0.645				0.045				0.887
Tumor-free	44	17.7–136.6	50.6		35	15.1–118.5	34.2		43	32.5–1490.2	248.7		33	64.5–2046.8	261.4
Positive	6	39.0–95.0	58.2		3	29.5–55.3	33.2		5	309.4–1770.6	499.0		2	150.0–543.5	346.7

Bold P-value indicates statistical significance. P-value obtained from nonparametric Mann-Whitney U test, unless specified otherwise.

^aObtained from nonparametric Kruskal-Wallis test.

MIF, macrophage migration inhibitory factor; NE; not evaluable.