Table II.
Association between the numbers of CD4- and CD8-positive lymphocytes in hepatocellular carcinoma tumor stromal tissues, and patient clinicopathological characteristics.
| Clinicopathological characteristic | No. | CD4 T cells, n, mean ± SEM | P-value(s) | CD8 T cells, n, mean ± SEM | P-value(s) |
|---|---|---|---|---|---|
| Age at diagnosis, years | |||||
| ≤60 | 12 | 23.9±10.6 | 0.400 | 33.3±10.0 | 0.842 |
| >60 | 39 | 21.8±3.8 | 33.1±4.8 | ||
| Gender | |||||
| Male | 37 | 24.0±4.6 | 0.315 | 31.3±4.1 | 0.849 |
| Female | 14 | 17.2±5.9 | 37.8±11.5 | ||
| Tumor diameter, cm | |||||
| ≤5 | 40 | 23.1±4.4 | 0.519 | 36.5±4.8 | 0.022 |
| >5 | 11 | 19.4±7.2 | 21.9±8.9 | ||
| Differentiation status | |||||
| Well | 10 | 20.7±6.8 | 0.911 | 28.3±5.9 | 0.870 |
| 0.971 | 0.886 | ||||
| Moderately | 27 | 24.7±6.0 | 0.911 | 34.0±6.1 | 0.870 |
| 0.757 | 0.999 | ||||
| Poorly | 14 | 18.1±5.1 | 0.971 | 34.3±9.5 | 0.886 |
| 0.757 | 0.999 | ||||
| Edmondson stage | |||||
| I–II | 31 | 20.7±4.0 | 0.317 | 32.7±4.4 | 0.858 |
| III–IV | 20 | 27.4±8.6 | 36.7±11.5 | ||
| Background | |||||
| NCH | 3 | 8.8±5.5 | 0.894 | 5.3±3.9 | 0.530 |
| 0.154 | 0.149 | ||||
| 0.946 | 0.665 | ||||
| CH | 33 | 20.9±4.4 | 0.894 | 32.1±5.5 | 0.530 |
| 0.117 | 0.416 | ||||
| 0.997 | 0.996 | ||||
| PC | 4 | 54.9±25.3 | 0.154 | 59.0±19.9 | 0.149 |
| 0.117 | 0.416 | ||||
| 0.141 | 0.424 | ||||
| C | 11 | 18.9±5.7 | 0.946 | 29.7±6.8 | 0.665 |
| 0.997 | 0.996 | ||||
| 0.141 | 0.424 | ||||
| Nodule number | |||||
| Single | 43 | 22.2±4.1 | 0.728 | 32.7±4.8 | 0.368 |
| Double | 8 | 21.6±6.9 | 36.9±7.6 | ||
| Portal vein infiltration | |||||
| Yes | 9 | 24.1±8.0 | 0.652 | 43.2±16.4 | 0.942 |
| No | 42 | 22.0±4.1 | 31.3±3.8 | ||
| Hepatic vein invasion | |||||
| Yes | 15 | 22.5±6.2 | 0.879 | 42.0±10.5 | 0.558 |
| No | 36 | 22.5±4.6 | 31.2±4.1 | ||
| Infiltration into capsule | |||||
| Yes | 18 | 21.9±5.0 | 0.573 | 38.2±9.0 | 0.700 |
| No | 33 | 22.3±4.9 | 29.0±3.5 | ||
| TNM stage | |||||
| I–II | 31 | 23.9±5.3 | 0.978 | 31.8±4.9 | 0.867 |
| III–IV | 20 | 20.3±4.7 | 34.7±7.7 | ||
P-values were obtained with nonparametric Mann-Whitney U test or one-factor analysis of variance. Bold P-value denotes statistical significance. SEM, standard error of the mean; NCH, non-chronic hepatitis; CH, chronic hepatitis; PC, chronic hepatitis with cirrhotic changes; C, cirrhosis.