Table 2.
List of presumed causes of ESRD in included individuals as reported by the treating nephrologist using the old European Renal Association-European Dialysis and Transplant Association code list (14)
| Cause of ESRD | Total ESRD Cohort | First-Degree Relative with ESRD | ||
|---|---|---|---|---|
| N | Percent | N | Percent | |
| N total | 8203 | 100 | 313 | 100 |
| Hereditary disease category | 1004 | 12.1 | 173 | 55.3 |
| Adult polycystic kidney disease | 682 | 8.3 | 124 | 39.6 |
| Alport disease | 32 | 0.4 | 8 | 2.6 |
| Medullary cystic disease including nephronophtisis | 64 | 0.8 | 26 | 8.3 |
| Congenital renal hypoplasia | 35 | 0.4 | 1 | 0.3 |
| Congenital obstructive uropathy | 88 | 1.1 | 2 | 0.6 |
| Congenital renal or urinary tract dysplasia or malformations | 34 | 0.4 | 0 | 0.0 |
| Other hereditary causes | 69 | 0.8 | 12 | 3.8 |
| Glomerular disease category | 2437 | 29.7 | 73 | 23.3 |
| IgA nephropathy | 274 | 3.3 | 9 | 2.9 |
| Wegener disease | 127 | 1.5 | 1 | 0.3 |
| Systemic lupus erythematosus | 102 | 1.2 | 5 | 1.6 |
| Crescenteric nephritis | 99 | 1.2 | 1 | 0.3 |
| Membranoproliferative disease type | 82 | 1.0 | 1 | 0.3 |
| Membranous disease | 41 | 0.5 | 0 | |
| FSGS | 89 | 1.1 | 9 | 2.9 |
| Other systemic disease | 96 | 1.2 | 1 | 0.3 |
| GN histologically examined (cause not given above) | 580 | 7.1 | 17 | 5.4 |
| GN not histologically examined | 897 | 11.0 | 29 | 9.3 |
| Other GN | 50 | 0.6 | 0 | |
| Interstitial disease category | 834 | 10.2 | 21 | 6.7 |
| Pyelonephritis unspecified | 361 | 4.4 | 10 | 3.2 |
| Pyelonephritis with acquired obstructive uropathy | 229 | 2.8 | 2 | 0.6 |
| Vesicoureteric reflux | 59 | 0.7 | 3 | 0.9 |
| Interstitial nephritis, unspecified | 85 | 1.0 | 6 | 1.9 |
| Interstitial nephritis, drug related | 100 | 1.2 | 0 | 0.0 |
| Diabetes nephropathy category | 1110 | 13.5 | 18 | 5.8 |
| Diabetes mellitus type 1 | 585 | 7.1 | 12 | 3.8 |
| Diabetes mellitus type 2 | 525 | 6.4 | 6 | 1.9 |
| Hypertensive nephropathy category | 1653 | 20.2 | 19 | 6.1 |
| Renal vascular disease caused by malignant hypertension | 64 | 0.8 | 1 | 0.3 |
| Renal vascular disease caused by essential hypertension | 1467 | 17.9 | 15 | 4.8 |
| Other | 122 | 1.5 | 3 | 0.9 |
| Other causes category | 1165 | 14.2 | 9 | 2.9 |
| Ischemic disease | 92 | 1.1 | 1 | 0.3 |
| Multiple myeloma | 210 | 2.6 | 0 | 0.0 |
| Amyloidosis | 319 | 3.9 | 3 | 0.9 |
| Tubular or medullary necrosis, not reversible | 81 | 1.0 | 1 | 0.3 |
| Loss of kidney/kidney tumor | 114 | 1.4 | 1 | 0.3 |
| Other identified renal disorders | 76 | 0.9 | 0 | 0.0 |
| Unknown cause of ESRD | 273 | 3.3 | 3 | 0.9 |