Table 3.

Risk of ESRD and different causes of ESRD according to whether a first-degree relative had ESRD

First-Degree Relative with ESRD	N Total Cohort	N Individuals with ESRD	Rate of ESRD (per million yr)	Total Cohort		Cohort Born after 1952
				Relative Risk (95% Confidence Interval)	P Value	Relative Risk (95% Confidence Interval)	P Value
Risk of ESRD if relative with ESRD
No	5,092,088	7890	69 (68–71)	1.0 (reference)		1.0 (reference)
Yes	27,046	313	443 (395–494)	7.2 (6.5 to 8.1)	<0.001	10.2 (8.7 to 12)	<0.001
Risk of ESRD caused by hereditary nephropathy
No	5,092,088	831	7.3 (6.8–7.8)	1.0 (reference)		1.0 (reference)
Yes	27,046	173	245 (210–283)	36 (30 to 42)	<0.001	42 (33 to 53)	<0.001
Risk of ESRD caused by GN
No	5,092,088	2364	21 (20–22)	1.0 (reference)		1.0 (reference)
Yes	27,046	73	103 (81–128)	5.2 (4.1– to 6.6)	<0.001	6.1 (4.4 to 8.4)	<0.001
Risk of ESRD caused by interstitial nephritis
No	5,092,088	813	7.1 (6.7–7.6)	1.0 (reference)		1.0 (reference)
Yes	27,046	21	30 (18–44)	4.7 (3.1 to 7.3)	<0.001	9.3 (5.4 to 16)	<0.001
Risk of ESRD caused by diabetes mellitus
No	5,092,088	1092	9.6 (9.0–10.2)	1.0 (reference)		1.0 (reference)
Yes	27,046	18	26 (15–39)	2.6 (1.6 to 4.1)	<0.001	2.6 (1.3 to 5.0)	<0.01
Risk of ESRD caused by hypertensive nephropathy
No	5,092,088	1634	14 (14–15)	1.0 (reference)		1.0 (reference)
Yes	27,046	19	27 (16–40)	2.6 (1.6 to 4.1)	<0.001	2.0 (0.5 to 8.1)	0.30
Risk of ESRD caused by other causes
No	5,092,088	1156	10 (9.6–11)	1.0 (reference)		1.0 (reference)
Yes	27,046	9	13 (5.8–22)	1.6 (0.8 to 3.1)	0.20	2.1 (0.7 to 6.6)	0.20