Table 2.
Multilevel model analysis of the unadjusted and adjusted variations at the patient, facility, and geographic levels for the level of eGFR at dialysis initiation
Model | Intraclass Correlation (%) | Variance Estimate | SEM | P Value |
---|---|---|---|---|
eGFR as a continuous variablea | ||||
Unadjusted | ||||
Patient | 90.7 | 17.6 | 0.14 | <0.001 |
Facility | 6.6 | 1.3 | 0.28 | <0.001 |
Geography | 2.7 | 0.5 | 0.42 | 0.11 |
Fully adjusted | ||||
Patient | 96.9 | 12.9 | 0.10 | <0.001 |
Facility | 3.1 | 0.4 | 0.09 | <0.001 |
Geography | 0.0 | 0.0 | 0.00 | >0.99 |
eGFR≥10.5 ml/min per 1.73 m2a | ||||
Unadjusted | ||||
Patient | — | — | — | — |
Facility | 8.2 | 0.3 | 0.07 | <0.001 |
Geography | 2.6 | 0.1 | 0.09 | 0.26 |
Fully adjusted | ||||
Patient | — | — | — | — |
Facility | 4.5 | 0.2 | 0.04 | <0.001 |
Geography | 0.1 | 0.0 | 0.02 | 0.40 |
eGFR as a continuous variable and predialysis care>90 db | ||||
Unadjusted | ||||
Patient | 88.2 | 16.0 | 0.15 | <0.001 |
Facility | 8.7 | 1.6 | 0.34 | <0.001 |
Geography | 3.1 | 0.6 | 0.48 | 0.12 |
Fully adjusted | ||||
Patient | 95.7 | 11.9 | 0.11 | <0.001 |
Facility | 4.2 | 0.5 | 0.12 | <0.001 |
Geography | 0.2 | 0.0 | 0.07 | 0.38 |
The patient-level intraclass correlation was not calculated for the binary outcome to avoid a fixed value assumption. The fully adjusted model included the following covariates: facility-level factors (percentage catheter use, transplantation facility, peritoneal dialysis facility, average hemoglobin and phosphate, average distance that a patient resided from the nearest dialysis center, and number of patients), patient case mix (age, sex, body mass index, race, comorbidities, distance to facility, length of predialysis care, peritoneal dialysis, serum phosphate, albumin, and hemoglobin), and year.
Geographic regions, 12; facilities, 63; patients, 33,263. Median number of patients per facility=795 (interquartile range=532–1053).
Geographic regions, 14; facilities, 63; patients, 23,902. Median number of patients per facility=795 (interquartile range=532–963).