Table III.

Univariate and multivariate analyses for overall survival (Cox’s proportional hazards regression model).

	Univariate analysis			Multivariate analysis
Factors	HR	95% CI	P-value	HR	95% CI	P-value
Age, years (<68/≥68)	5.43	1.42–35.40	0.010*	2.58	0.52–18.92	0.252
Gender (male/female)	1.96	0.58–8.84	0.288
Histological grade (poor/well-moderate)	0.01	0.00–3.02	0.495
Tumor size, mm (≥30/<30)	1.13	0.58–2.90	0.731
Tumor invasion (T4/Tis-3)	2.47	1.39–4.54	0.002*	2.21	1.09–5.02	0.026*
Lymph node metastasis (N1–2/N0)	6.88	2.04–31.12	0.001*	2.07	0.45–10.76	0.342
Lymphatic invasion (present/absent)	5.31	1.39–34.63	0.012*	1.49	0.29–10.93	0.640
Venous invasion (present/absent)	3.78	1.17–12.14	0.026*	2.77	0.77–10.59	0.116
Distant metastasis (M1/M0)	10.82	3.08–35.36	<0.001*	16.64	2.92–132.64	0.001*
ANXA9 expression (high/low)	3.00	1.32–12.86	0.004*	3.13	1.30–13.69	0.007*

^*Statistically significant.

HR, hazard ratio; CI, confidence interval; ANXA9, annexin A9.