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Downregulation of DNMT1 mRNA and protein expression by siRNA in human RPMI-8226 cells. (A) Quantitative polymerase chain reaction was used to analyze DNMT1 mRNA expression. (B) Western blot analysis of DNMT1 protein expression. The data are from three independent experiments, ***P<0.0001, compared with the negative control group and the non-transfected control group. DNMT1, DNA methyltransferase 1.
