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Effect of DNMT1 knockdown on the cell cycle. Cells were subjected to propidium iodide staining and flow cytometry analysis. Compared with the untransfected cells, treatment with DNMT1 siRNA increased the number of cells in the G0/G1 phase, while reducing the number of cells in S and G2/M phases. (A) siRNA-DNMT1 and (B) RPMI-8226 groups. All the experiments measuring cell cycle were repeated three times. DNMT1, DNA methyltransferase 1
