Table III.
Univariate and multivariate analysis of risk factors for recurrence-free survival in stage 0-III colorectal cancer patients.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
|
|
|
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| Factor | HR | 95% CI | P-value | HR | 95% | CI P-value |
| Age, years (>60/≤60) | 0.639 | 0.287–1.409 | 0.264 | |||
| Gender (male/female) | 0.541 | 0.229–1.120 | 0.132 | |||
| Tumor location (proximal/distal) | 0.683 | 0.278–1.536 | 0.364 | |||
| Tumor size, mm (<44/≥44) | 0.961 | 0.435–2.134 | 0.919 | |||
| Histology (diff/undiff) | 0.872 | 0.302–3.686 | 0.827 | |||
| Depth of tumor (T0–2/T3, T4) | 0.416 | 0.098–1.201 | 0.112 | |||
| Tumor stage (stage 0-II/III) | 0.247 | 0.096–0.568 | 0.001 | 0.395 | 0.146–0.969 | 0.042 |
| Pathological lymphatic invasion (negative/positive) | 0.448 | 0.189–0.994 | 0.048 | 0.527 | 0.220–1.187 | 0.123 |
| Pathological venous invasion (negative/positive) | 0.305 | 0.135–0.674 | 0.004 | 0.503 | 0.212–1.156 | 0.106 |
| Post-operative chemotherapy (yes/no) | 0.722 | 0.295–1.624 | 0.440 | |||
| CIMP status (CIMP-H/L/N) | 0.167 | 0.001–0.789 | 0.019 | 0.292 | 0.016–1.421 | 0.149 |
| MLH1 methylation (positive/negative) | <0.001 | 0.601–0.601 | 0.013 | <0.001 | <0.001–1.888 | 0.141 |
Diff, differentiated; undiff, undifferentiated; CI, confidence interval; CIMP, CpG island methylator phenotype; CIMP-H, CIMP-high; CIMP-L, CIMP-low; CIMP-N, CIMP-negative; MLH1, MutL homolog 1.