Table III.
Univariate and multivariate analysis of OS using Cox’s proportional hazard model.
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
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|
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| Parameter | Number of cases | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (>65 years) | 78/113 | 1.24 (0.84–1.84) | 0.2766 | ||
| Gender (female/male) | 24/167 | 1.05 (0.56–1.82) | 0.8591 | ||
| Histology (poor-moderate/well)a | 144/47 | 1.94 (1.18–3.49) | 0.0082 | 1.87 (1.13–3.29) | 0.0134 |
| pT (T3,4/T1,2)b | 110/81 | 2.34 (1.55–3.62) | <0.0001 | 1.28 (0.79–2.10) | 0.3303 |
| pN (N1–3, N0)b | 123/68 | 2.85 (1.81–4.69) | <0.0001 | 2.19 (1.36–3.66) | 0.0010 |
| Lympathic invasion (present/absent) | 148/43 | 2.08 (1.26–3.70) | 0.0036 | 1.11 (0.62–2.08) | 0.7354 |
| Venous invasion (present/absent) | 79/112 | 1.79 (1.21–2.64) | 0.0039 | 1.22 (0.79–1.91) | 0.3740 |
| NAC (yes/no) | 86/105 | 2.01 (1.35–3.00) | 0.0005 | 1.88 (1.24–2.86) | 0.0028 |
| IMP3 expression (positive/negative) | 113/78 | 2.12 (1.40–3.29) | 0.0003 | 1.84 (1.18–2.93) | 0.0064 |
a
Well-, moderately- and poorly-differentiated squamous cell carcinoma.
b
According to the Union for International Cancer Control, 7th edition (21).
OS, overall survival; pN; pathological N stage; pT, pathological T stage; HR, hazard ratio; CI, confidence interval; IMP3, insulin-like growth factor-II mRNA-binding protein-3; NAC, neoadjuvant chemotherapy.